Initial ultrasound and blood tests help to determine the best time for retrieving the eggs. Some cases may also be asked to take stimulating pills or suppository hormones prior to the procedure.
IVM and use of medication
While there is extremely low need to stimulating hormones, yet, a major concern in IVM is the preparation of the uterus for implantation in only a few days after retrieval and the time embryo is transferred. What is mainly advised to prepare uterus internal layer, consists of 2 to 4 mg daily of estradiol valerate from the oocyte retrieval. Intravaginal progesterone also may start up to 48 hours later at the time of microinjection or insemination.
IVM common risks and side effects
After the operation, if the doctor finds the cycle successful, the newly pregnant woman will start her post-treatment cares and medications. However, in some cases, the cycle is not successful, and the couple may need to undergo another cycle of IVM. This condition may be accompanied by a feeling of depression and disappointment in them. Generally, the rate of implantation decreases as women age, therefore, more embryos may be agreed to be implanted to increase the likelihood of success. In that case, like with any type of artificial reproductive option, if a greater number of embryos is transferred, it would increase chances of having multiple pregnancies. IVM process is relatively new. Whilst it is safer, simpler and cheaper, the success rate is half in each cycle compared to IVF. Because less medication is used, there is the possibility that fewer eggs be retrieval. There is also the possibility that all immature eggs will not be matured in the lab, resulting in a smaller number of viable eggs for IVF treatment. The treatment can be followed by inflammation of breasts, bloating, constipation and light muscle cramps as side effects.
Post-operative embryo transfer
One to two hours after the embryo transfer, the patient can be discharged and resume their daily activities. It is recommended to avoid strenuous activities that can lead to excessive fatigue during 3-4 days after the operation. Certainly, mental and psychological relaxation and avoiding extreme anxiety conditions can be effective in the success of the operation. Patients should contact their doctors if faced severe discomfort or pain after the surgery. Usually, 10 to 12 days after the embryo was transferred, the patient needs to return, so blood levels of BHCG can be measured. The increase in this hormone is the first sign of pregnancy.
IVM in Iran
Because In-Vitro Maturation is a complicated procedure, not every fertility center offers this treatment. However, highly equipped fertility clinics and institutes in Iran, such as “Royan Institute”, “Avicenna Fertility Clinic” and “Reproductive Sciences Institute” in Yazd offer their services at a global level. The provision of fertility treatment services has made these centers known as leading centers in infertility treatment. Specialized clinics of these centers, has made their treatments more comprehensive and privileged than the past, providing diagnostic services, including cytology and genetic tests, ultrasound and radiography as well as the provision of all fertility-related advice such as nutrition, psychiatry, genetics and sexual health. Patients are welcomed from around the world to receive quality treatments in these centers.